Health

The core foundations of human health.

AgingAI HealthAlcoholCancerExerciseEyesFoodHairHealth liesSleepStressSupplementsTeethVarious Health

Aging

All Aging (70) »
lab skin cells clock

Partial reprogramming shifted lab skin cells toward younger clocks

In a 2022 eLife study, researchers at the Babraham Institute and partner institutions used 13 days of maturation-phase transient reprogramming on middle-aged donors' skin fibroblasts and reported roughly thirty-year shifts on custom transcript and DNA methylation clocks, plus collagen-related signals and partial gains in a scratch-wound assay. Cells regained fibroblast identity in the dish; telomere lengthening was not seen on the methylation-based estimate used. FDA later cleared a separate company-sponsored phase 1 gene-therapy trial based on partial epigenetic reprogramming for optic neuropathies; starting that trial is not proof of anti-aging benefit in humans.

memory rejuvenation

Memory rejuvenation restored recall in mice

An EPFL Neuron study found that brief OSK gene activation in memory-trace neurons improved recall in aged and Alzheimer's-model mice. The result suggests some memory decline may reflect aging neurons rather than erased memories, but it does not show human memory restoration.

aging cancer

Aging is the biggest overall cancer risk factor

Aging is the biggest overall cancer risk factor, but that does not make preventable risks irrelevant. The stronger message is that older adults with cancer need care that fits their full health status, not only the tumor.

Vision gains in early dry AMD stem cell transplant trial

An open-label phase 1/2a report in Cell Stem Cell covers the first six participants in the lowest-dose arm of a donor-derived RPE stem cell trial for geographic atrophy. Chart scores in the poorest-vision group rose on average at a 12-month visit, and the better-vision group showed a modest average gain at six months, but the cohort is too small and too early to treat as proof of efficacy or as standard care.

AI Health

All AI Health (12) »

Alcohol

All Alcohol (16) »
drinking consequences

Heavy drinking is linked to earlier brain bleeding

In 1,600 people already hospitalized with spontaneous brain bleeds, heavy regular drinking was associated with earlier median age at onset (64 vs 75 years), larger hematomas, and MRI patterns suggesting more advanced small-vessel disease versus the non-HAU cohort. The Neurology study is cross-sectional and single-center, so it reports associations in admitted patients, not proof of direct causation for each finding.

Cancer

All Cancer (10) »
aging cancer

Aging is the biggest overall cancer risk factor

Aging is the biggest overall cancer risk factor, but that does not make preventable risks irrelevant. The stronger message is that older adults with cancer need care that fits their full health status, not only the tumor.

PAHs in food form during high-heat cooking

PAHs can form in food during smoking, grilling, and other high-heat processes. A 2025 paper mainly validates a faster lab method to detect eight PAHs in food matrices, rather than proving that everyday foods are broadly dangerous.

Exercise

All Exercise (75) »
weight before cardio

Cardio before or after weights? Match order to your goal

For many gym-goers, sticking to training matters more than perfect order. Cleveland Clinic ties sequence to goals (endurance first, strength first) and, for weight loss, to what you will actually do. A 2025 trial in forty-five young men with obesity favored resistance-before-cycling for fat mass, body fat percentage, android versus gynoid fat, and MVPA, with similar aerobic fitness either way. Hindustan Times coach quotes are user-generated and unverified by the outlet.

Eyes

All Eyes (2) »

Vision gains in early dry AMD stem cell transplant trial

An open-label phase 1/2a report in Cell Stem Cell covers the first six participants in the lowest-dose arm of a donor-derived RPE stem cell trial for geographic atrophy. Chart scores in the poorest-vision group rose on average at a 12-month visit, and the better-vision group showed a modest average gain at six months, but the cohort is too small and too early to treat as proof of efficacy or as standard care.

Food

All Food (46) »

HSL helps maintain fat tissue from inside the nucleus

A Cell Metabolism study (first published online 23 October 2025) reports that hormone-sensitive lipase (HSL) is active on fat droplets and in fat-cell nuclei, where it helps maintain adipose tissue. In the mouse models and rare human HSL-deficiency cases described in the paper, the phenotype is lipodystrophy (abnormal loss or redistribution of fat tissue), not obesity. The work reframes how too much and too little functional fat tissue can both strain metabolism. It does not replace medical or lifestyle advice or prove any new treatment.

Frozen vegetables are a healthy choice

Frozen vegetables rival fresh produce on nutrients, price and safety Many shoppers assume that “fresh” automatically means “healthier,” yet freezing…

Hair

All Hair (9) »

Health Lies

All Health lies (10) »
sleeping naked

Sleeping naked is not proven to extend lifespan

Headlines that tie nudity to extra years of life are not backed by serious longevity research. What holds up in sources is narrower: heat at night often fragments sleep, public health pages recommend a cool bedroom, and one home-based study in community-dwelling older adults points to a 20-25 °C band under nonlinear models with large person-to-person differences. Choosing pajamas is personal; comfort and room temperature matter more than anti-aging slogans.

Sleep

All Sleep (40) »
lab skin cells clock

Partial reprogramming shifted lab skin cells toward younger clocks

In a 2022 eLife study, researchers at the Babraham Institute and partner institutions used 13 days of maturation-phase transient reprogramming on middle-aged donors' skin fibroblasts and reported roughly thirty-year shifts on custom transcript and DNA methylation clocks, plus collagen-related signals and partial gains in a scratch-wound assay. Cells regained fibroblast identity in the dish; telomere lengthening was not seen on the methylation-based estimate used. FDA later cleared a separate company-sponsored phase 1 gene-therapy trial based on partial epigenetic reprogramming for optic neuropathies; starting that trial is not proof of anti-aging benefit in humans.

memory rejuvenation

Memory rejuvenation restored recall in mice

An EPFL Neuron study found that brief OSK gene activation in memory-trace neurons improved recall in aged and Alzheimer's-model mice. The result suggests some memory decline may reflect aging neurons rather than erased memories, but it does not show human memory restoration.

pill that cut LDL

A new cholesterol pill cut bad cholesterol by about 60% in a large trial

CORALreef Lipids is now peer-reviewed in the NEJM (4 February 2026): once-daily oral enlicitide decanoate on top of statins in most participants cut LDL cholesterol by about 56 percentage points versus placebo at 24 weeks, with similar short-term adverse-event rates in the trial. Cardiovascular outcome benefit for this oral drug is still unproven until CORALreef Outcomes reports.

Stress

All Stress (36) »
GRIK4 anxiety

Fixing one gene’s activity reversed anxiety signs in mice

Researchers identified regular-firing neurons in the centrolateral amygdala that drive anxiety behaviors. Normalizing GRIK4 gene dosage in basolateral amygdala pyramidal cells reversed anxiety, depression, and social deficits in mice overexpressing the gene, suggesting a targeted treatment approach for anxiety disorders.

Amygdala circuit tweak clears anxiety signs in mice

A May 2025 iScience mouse study (online 13 May 2025; print issue 20 June 2025) reports that normalizing Grik4 in basolateral amygdala pyramidal cells reversed anxiety-like behavior, depression-like behavior, and social deficits in a transgenic model, while object recognition stayed impaired. In non-transgenic mice that were already highly anxious on screening, the same approach yielded only partial relief of anxiety-like behavior on the elevated plus maze, not a broad reversal across domains. The work is preclinical and does not establish a human treatment.

Men’s mental health: care gaps and suicide risk in U.S. data

National U.S. surveys show that mental illness is common among men, that men who have a mental illness are less likely than women in the same situation to use mental health services, and that suicide deaths fall very heavily on males. Cultural pressure to stay tough and stoic is often discussed as one possible barrier to opening up and getting treatment, but the NIMH and CDC summaries cited here do not test or quantify that explanation.

Supplements

All Supplements (37) »

Teeth

All Teeth (8) »
tooth regrowth

Drug to regrow teeth moves closer to clinical use

A drug that blocks the USAG-1 protein could enable natural tooth regrowth in humans. Kitano Hospital reports that an investigator-initiated Phase I trial is underway at Kyoto University Hospital (Ki-CONNECT) from September 2024 to August 2025. The researchers aim to make the treatment available by 2030 for people with congenital tooth loss.

Various Health

All Various Health (35) »
pill that cut LDL

A new cholesterol pill cut bad cholesterol by about 60% in a large trial

CORALreef Lipids is now peer-reviewed in the NEJM (4 February 2026): once-daily oral enlicitide decanoate on top of statins in most participants cut LDL cholesterol by about 56 percentage points versus placebo at 24 weeks, with similar short-term adverse-event rates in the trial. Cardiovascular outcome benefit for this oral drug is still unproven until CORALreef Outcomes reports.

HSL helps maintain fat tissue from inside the nucleus

A Cell Metabolism study (first published online 23 October 2025) reports that hormone-sensitive lipase (HSL) is active on fat droplets and in fat-cell nuclei, where it helps maintain adipose tissue. In the mouse models and rare human HSL-deficiency cases described in the paper, the phenotype is lipodystrophy (abnormal loss or redistribution of fat tissue), not obesity. The work reframes how too much and too little functional fat tissue can both strain metabolism. It does not replace medical or lifestyle advice or prove any new treatment.

Bedroom night light ties to higher heart and stroke risk

In 88,905 adults followed with wrist light sensors, brighter nights were tied to higher future risks of coronary disease, heart attack, heart failure, atrial fibrillation, and stroke under the paper's primary model 3 (demographics, socioeconomic factors, physical activity, smoking, alcohol, diet, and urbanicity). That pattern is association, not proof that your bedroom lamp causes disease. A lab study in healthy young adults found one night of moderate room light during sleep caused a higher nighttime heart rate and lower heart-rate variability and showed higher HOMA-IR, higher 30-minute insulin area under the curve, and a lower Matsuda index the next morning versus very dim light. For everyday sleep space habits, the CDC recommends a cool, dark, quiet bedroom and limiting bright artificial light before bed.