Research shows lifestyle outweighs genetics for lifespan and healthspan. Evidence-based ways to slow biological aging that lift daily life right away: more energy, better mood, deeper sleep, sharper focus, better health, and, through clearer thinking and steadier emotions, better relationships.
Larry Ellison, the 80-year-old billionaire cofounder of Oracle, is being praised for looking decades younger. Longevity advocate Bryan Johnson highlighted Ellison’s appearance, crediting his anti-aging regimen. Ellison maintains a strict diet, exercises regularly, and avoids alcohol. Some speculate about possible…
According to a doctor (A.M.) about another doctor (Résimont) about another doctor (Eric Müller) : IN PRACTICE: If deficient (<60): start with 40,000 IU per week, then retest in 3 months. If normal (60-80): maintenance dose at 30,000 IU per…
the rapid advancements in anti-aging medicine, emphasizing the potential of wearables, implantable devices, and biological age clocks to transform healthcare. Remote monitoring, telemedicine, and at-home diagnostic tests are becoming commonplace, reshaping how diseases like cancer and heart conditions are detected…
the molecular and lifestyle interventions to slow cognitive decline and diseases like Alzheimer’s. Key points include the importance of longevity pathways (Sirtuins, AMPK, mTOR), the benefits of a Mediterranean diet, omega-3 fatty acids, and aerobic exercise. Supplements like NAD boosters…
Harvard professor David Sinclair and co-host Matthew LaPlante discuss methods to slow or reverse cosmetic aging, focusing on skin, hair, and nails. They examine treatments such as hormone therapy, retinoids, collagen supplements, peptides, and Botox. Emphasis is placed on approaches…
Advanced medical interventions for longevity, including stem cell therapy, testosterone replacement, human growth hormone (HGH), and cellular reprogramming. While testosterone and HGH provide short-term benefits, their long-term effects may accelerate aging. Peptides and exosome therapy show promise in enhancing cell…
David Sinclair and Matthew LaPlante dive into various supplements and drugs believed to support longevity. Key substances include NAD boosters (NR and NMN), Metformin, resveratrol, fisetin, and quercetin. They discuss the benefits, risks, and science behind these compounds, emphasizing their…
The importance of exercise and adversity mimetics in activating longevity pathways. David Sinclair explains how vigorous exercise, intermittent fasting, and exposure to temperature extremes (cold and heat) mimic biological adversity, turning on protective genes like mTOR, AMPK, and sirtuins. These…
Intermittent Fasting (IF): Eating within a restricted time window, like 16–20 hours of fasting daily, helps activate longevity pathways, reduce body fat, and stabilize glucose levels. Over time, this approach reduces hunger and enhances focus. Fasting Benefits: Fasting triggers autophagy…