Aging
Research shows lifestyle is more important than genetics for lifespan and healthspan. Evidence-based ways to slow biological aging that improve daily life right away: more energy, better mood, deeper sleep, sharper focus, better health, and, through clearer thinking and steadier emotions, better relationships.
Level 1
Aging is the biggest overall cancer risk factor
Aging is the biggest overall cancer risk factor, but that does not make preventable risks irrelevant. The stronger message is that older adults with cancer need care that fits their full health status, not only the tumor.
People do not die of old age: aging weakens the body and disease causes death
A common phrase says someone “died of old age.” Medicine says otherwise. Doctors do not certify “old age” as a…
Plant protein and fish are linked with longer life, while red and processed meat raise risk
A recent media claim said that eating a lot of animal protein speeds aging. The idea has some truth, but…
Lifestyle counts far more than genetics for health and longevity
75-90 % of what determines human lifespan lies outside the DNA we inherit. That “environmental” portion is overwhelmingly shaped by lifestyle: medical care, nutrition, physical activity, smoking, social support, and more.
We create a false self in early life to meet external expectations and cope with childhood experiences – James Hollis
James Hollis explores the psychological and spiritual upheaval of midlife as a necessary and meaningful rite of passage. Drawing from…
Ultra-processed foods linked to weaker muscles and higher fat in thighs
A UCSF study finds eating ultra-processed foods adds fat to thigh muscles, making them weaker and raising arthritis risk, even if you exercise.
Walking like the most active people could add 5 to 11 years to life
A new study finds that matching the activity level of the top 25% of Americans could add 5 years to life expectancy, and up to 11 years for the inactive.
videoSupplements and drugs most discussed for living longer
David Sinclair and Matthew LaPlante dive into various supplements and drugs believed to support longevity. Key substances include NAD boosters…
videoMeal timing and food choices that support health
Intermittent Fasting (IF): Eating within a restricted time window, like 16–20 hours of fasting daily, helps activate longevity pathways, reduce…
Level 2
Low vitamin D and K levels tripled heart disease risk in one study
According to a doctor (A.M.) about another doctor (Résimont) about another doctor (Eric Müller) : IN PRACTICE: If deficient (<60):…
videoPractical ways to keep your brain sharp as you age
the molecular and lifestyle interventions to slow cognitive decline and diseases like Alzheimer’s. Key points include the importance of longevity…
videoHow to slow visible aging in skin, nails, and hair
Harvard professor David Sinclair and co-host Matthew LaPlante discuss methods to slow or reverse cosmetic aging, focusing on skin, hair,…
videoHow exercise, sauna, and cold exposure may slow aging
The importance of exercise and adversity mimetics in activating longevity pathways. David Sinclair explains how vigorous exercise, intermittent fasting, and…
videoAging is a controllable process that can be slowed and reversed
The podcast “Lifespan” by Dr. David Sinclair, a Harvard Medical School professor, explores the science of aging and how to…
What the world’s longest-lived people eat for breakfast
Research on centenarians’ diets suggests the world’s healthiest breakfast includes whole grains, such as oats, paired with plant-based proteins like…
Level 3
Partial reprogramming shifted lab skin cells toward younger clocks
In a 2022 eLife study, researchers at the Babraham Institute and partner institutions used 13 days of maturation-phase transient reprogramming on middle-aged donors' skin fibroblasts and reported roughly thirty-year shifts on custom transcript and DNA methylation clocks, plus collagen-related signals and partial gains in a scratch-wound assay. Cells regained fibroblast identity in the dish; telomere lengthening was not seen on the methylation-based estimate used. FDA later cleared a separate company-sponsored phase 1 gene-therapy trial based on partial epigenetic reprogramming for optic neuropathies; starting that trial is not proof of anti-aging benefit in humans.
Memory rejuvenation restored recall in mice
An EPFL Neuron study found that brief OSK gene activation in memory-trace neurons improved recall in aged and Alzheimer's-model mice. The result suggests some memory decline may reflect aging neurons rather than erased memories, but it does not show human memory restoration.
Vision gains in early dry AMD stem cell transplant trial
An open-label phase 1/2a report in Cell Stem Cell covers the first six participants in the lowest-dose arm of a donor-derived RPE stem cell trial for geographic atrophy. Chart scores in the poorest-vision group rose on average at a 12-month visit, and the better-vision group showed a modest average gain at six months, but the cohort is too small and too early to treat as proof of efficacy or as standard care.
AI-designed Yamanaka factors may speed cell rejuvenation research
AI-designed Yamanaka factors may speed cell rejuvenation research, but the current evidence still points to early lab progress rather than a near-term anti-aging treatment.
Healing the liver to achieve sustainable weight loss without frustration by Dr. Réginald Allouche
According to Dr. Réginald Allouche, weight gain is not merely caused by overeating but by an overburdened liver that can…
Clearing a protein buildup in the brain extended fly lifespan by 30%
A UCLA study found that preventing F-actin accumulation in the brain restores autophagy and extends fruit fly lifespan by 30%, offering new anti-aging hope.