Aging - All posts
This archives page shows all posts of this category. Go back to category guide: Aging »
Partial reprogramming shifted lab skin cells toward younger clocks
In a 2022 eLife study, researchers at the Babraham Institute and partner institutions used 13 days of maturation-phase transient reprogramming on middle-aged donors' skin fibroblasts and reported roughly thirty-year shifts on custom transcript and DNA methylation clocks, plus collagen-related signals and partial gains in a scratch-wound assay. Cells regained fibroblast identity in the dish; telomere lengthening was not seen on the methylation-based estimate used. FDA later cleared a separate company-sponsored phase 1 gene-therapy trial based on partial epigenetic reprogramming for optic neuropathies; starting that trial is not proof of anti-aging benefit in humans.
Memory rejuvenation restored recall in mice
An EPFL Neuron study found that brief OSK gene activation in memory-trace neurons improved recall in aged and Alzheimer's-model mice. The result suggests some memory decline may reflect aging neurons rather than erased memories, but it does not show human memory restoration.
DHEA benefits are limited, and anti-aging proof is weak
DHEA is a real hormone precursor, and its level falls with age. But that does not prove oral DHEA improves aging, energy, muscle, or libido for most people. Human evidence supports a few narrower uses and raises real safety questions.
Bryan Johnson’s Blueprint and “Don’t Die” movement aim to make death optional
Bryan Johnson's Blueprint project uses data to reverse aging. His "Don't Die" movement aims to make longevity humanity's top goal through healthy habits.
NAD supplements help cells produce energy (but anti-aging proof in humans is still limited)
NAD supplements like NMN and NR help cells produce energy and may fight aging. Learn how they work, what science says about their benefits, and the risks.
Aging is the biggest overall cancer risk factor
Aging is the biggest overall cancer risk factor, but that does not make preventable risks irrelevant. The stronger message is that older adults with cancer need care that fits their full health status, not only the tumor.
Can you reverse gray hair? Science says probably not permanently
While genetics is the main factor, reducing personal and environmental stress can temporarily reverse gray hair color in some cases, but a permanent fix is not yet available.
Vision gains in early dry AMD stem cell transplant trial
An open-label phase 1/2a report in Cell Stem Cell covers the first six participants in the lowest-dose arm of a donor-derived RPE stem cell trial for geographic atrophy. Chart scores in the poorest-vision group rose on average at a 12-month visit, and the better-vision group showed a modest average gain at six months, but the cohort is too small and too early to treat as proof of efficacy or as standard care.
Artificial sweeteners may speed cognitive decline
A large observational study linked higher intake of several artificial sweeteners to faster cognitive decline over about eight years, but it did not prove causation.