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pill that cut LDL

A new cholesterol pill cut bad cholesterol by about 60% in a large trial

CORALreef Lipids is now peer-reviewed in the NEJM (4 February 2026): once-daily oral enlicitide decanoate on top of statins in most participants cut LDL cholesterol by about 56 percentage points versus placebo at 24 weeks, with similar short-term adverse-event rates in the trial. Cardiovascular outcome benefit for this oral drug is still unproven until CORALreef Outcomes reports.

HSL helps maintain fat tissue from inside the nucleus

A Cell Metabolism study (first published online 23 October 2025) reports that hormone-sensitive lipase (HSL) is active on fat droplets and in fat-cell nuclei, where it helps maintain adipose tissue. In the mouse models and rare human HSL-deficiency cases described in the paper, the phenotype is lipodystrophy (abnormal loss or redistribution of fat tissue), not obesity. The work reframes how too much and too little functional fat tissue can both strain metabolism. It does not replace medical or lifestyle advice or prove any new treatment.

Bedroom night light ties to higher heart and stroke risk

In 88,905 adults followed with wrist light sensors, brighter nights were tied to higher future risks of coronary disease, heart attack, heart failure, atrial fibrillation, and stroke under the paper's primary model 3 (demographics, socioeconomic factors, physical activity, smoking, alcohol, diet, and urbanicity). That pattern is association, not proof that your bedroom lamp causes disease. A lab study in healthy young adults found one night of moderate room light during sleep caused a higher nighttime heart rate and lower heart-rate variability and showed higher HOMA-IR, higher 30-minute insulin area under the curve, and a lower Matsuda index the next morning versus very dim light. For everyday sleep space habits, the CDC recommends a cool, dark, quiet bedroom and limiting bright artificial light before bed.