Supplements
The biological impact of supplements on aging, cognition, and physical performance. Molecular discoveries, hormone regulation, and the safety profiles of everyday essentials.
Essentials
videoSupplements and drugs most discussed for living longer
David Sinclair and Matthew LaPlante dive into various supplements and drugs believed to support longevity. Key substances include NAD boosters…
What Works
DHEA benefits are limited, and anti-aging proof is weak
DHEA is a real hormone precursor, and its level falls with age. But that does not prove oral DHEA improves aging, energy, muscle, or libido for most people. Human evidence supports a few narrower uses and raises real safety questions.
NMN and NR supplements raise blood NAD but have not slowed aging in humans
NMN and NR supplements reliably raise blood NAD, but human trials have not shown that they slow aging; measured benefits so far are small and inconsistent.
NAD supplements raise NAD in the body – health gains are not established yet
Nicotinamide adenine dinucleotide, or NAD, is a helper molecule that cells use for energy, DNA repair, and body clock control.…
Vitamin D may help cells age more slowly
Vitamin D may slow cellular aging by preserving telomere length, a new study finds. Learn about the benefits for DNA, proper dosage, and potential risks.
Low vitamin D and K levels tripled heart disease risk in one study
According to a doctor (A.M.) about another doctor (Résimont) about another doctor (Eric Müller) : IN PRACTICE: If deficient (<60):…
videoPractical ways to keep your brain sharp as you age
the molecular and lifestyle interventions to slow cognitive decline and diseases like Alzheimer’s. Key points include the importance of longevity…
Early Trials
Fish oil supplements may be worthless
Studies have shown that the omega-3 fatty acids found in fish such as salmon and mackerel provide health benefits, but…
A new type of drug targets aging cells to slow decline
Senolytics are a class of drugs designed to selectively eliminate senescent cells, which accumulate with age and contribute to aging-related…
Creatine supplement may help relieve some long COVID symptoms
Research shows that creatine has many benefits, including help improve strength and power, and support recovery between workouts. Creatine also appears to have a positive effect on some self-reported long COVID symptoms (but not physical fatigue). More research is needed.
NMN anti-aging supplement appears safe in early human trials
NMN is a molecule that may be useful in slowing down some aspects of aging. NMN is a precursor of NAD+.
NAD+ serves many critical functions in human cells, such as electron transport, cell signaling, and DNA repair, and is essential in processes like metabolism, cell death, aging, DNA repair, gene expression, or neuroinflammation.
Rapamycin may slow aging in animals and help older immune systems
Rapamycin is a credible anti aging candidate based on strong animal data and early human immune results, but it is not yet proven to extend human lifespan. More randomized trials in people are in progress.
Matcha can be healthy in small, unsweetened servings, say experts
Matcha is a safe, potentially beneficial drink when used in moderation and without added sugar, but its reputation still runs…