Neuroscience

Insights into the biological foundations of consciousness and the human experience.

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GRIK4 anxiety

Fixing one gene’s activity reversed anxiety signs in mice

Researchers identified regular-firing neurons in the centrolateral amygdala that drive anxiety behaviors. Normalizing GRIK4 gene dosage in basolateral amygdala pyramidal cells reversed anxiety, depression, and social deficits in mice overexpressing the gene, suggesting a targeted treatment approach for anxiety disorders.

Amygdala circuit tweak clears anxiety signs in mice

A May 2025 iScience mouse study (online 13 May 2025; print issue 20 June 2025) reports that normalizing Grik4 in basolateral amygdala pyramidal cells reversed anxiety-like behavior, depression-like behavior, and social deficits in a transgenic model, while object recognition stayed impaired. In non-transgenic mice that were already highly anxious on screening, the same approach yielded only partial relief of anxiety-like behavior on the elevated plus maze, not a broad reversal across domains. The work is preclinical and does not establish a human treatment.